The fact that silencing the NMT1 and CKIIα genes blocked the infection of human cells by HIV-1 CRF02_AG but not clade-B viruses, suggests that the additional N-myristoylation and CKII domains present in Tat.AG sequences are functional and directly modulate the replication of CRF02_AG viruses. Here, RENBP is linked to infection.