Of note, the expression pattern differed between HCV-specific MHC class I/II tetramer+ CD8+ and CD4+ T cells: TIGIT expression level of MHC class I HCV-specific CD8+ T cells was generally lower in acute and spontaneously resolved HCV infection but much higher in patients with chronic (chronic vs acute: p = 0,0162, chronic vs resolved: p = 0,0056) HCV infection (Fig. 6A,B). This evidence concerns the gene CD4 and infection.