ICAM1 and neoplasm: Given the cross-reactivity of the human LFA-1 I domain with murine ICAM-1 and comparable CAR T cytotoxicity towards target cells expressing either human or murine ICAM-1, we were able to show the utility of our mouse model to examine the on-target, off-tumor toxicity of our CAR T cells concurrently with on-target, on-tumor efficacy.