In another recent large-scale study by Shiga et al. [24] in the Japanese population, variants near cyclin-dependent kinase inhibitor 2B-antisense 1 (CDKN2B-AS1, rs2157719), SIX Homeobox 6 (SIX6, rs33912345) and growth arrest-specific 7 (GAS7, rs9913911) were found to be associated with POAG. This evidence concerns the gene SIX6 and open-angle glaucoma.