Zeng et al. [53] found that in the hyperglycemic environment, the sensitivity of breast cancer cells to chemotherapeutic drugs (such as 5-FU, doxorubicin or paclitaxel) might be related to fatty acid synthase (FAS), since inhibiting fatty acid synthase restored the sensitivity and accelerated the apoptosis of breast cancer cells. This evidence concerns the gene FAS and breast carcinoma.