IGFBP2 and Familial prostate cancer: However, Xu et al. [62] revealed that pre-existing high-risk factors such as hyperglycemia or obesity were associated with poor prognosis of prostate cancer; Li et al. [22] pointed out that hyperglycemia increased the expression of miR-301a in prostate cancer cells, thereby promoting G1/S cell cycle transition in vivo and accelerating cell proliferation; Biernacka et al. [50, 51] found that high glucose inhibited the efficacy of docetaxel-induced apoptosis in prostate cancer cells, which may be associated with hyperglycemia-mediated IGFBP2 overproduction.