Investigation of the potential role of Alpha-1-antitrypsin (SERPINA1) expression in cancers provides controversial results; it has been associated with good prognosis in breast and colon cancer on protein atlas [37] (https://www.proteinatlas.org/ENSG00000197249-SERPINA1/pathology), but there are also reports that associate it with poor prognosis in colon cancer [38], gastric cancer [39] and cutaneous squamous cell carcinoma [40]. Here, SERPINA1 is linked to malignant colon neoplasm.