RYR2 and catecholaminergic polymorphic ventricular tachycardia: The complete sequencing of RYR2 with NGS appears to contribute additional yield over limited exon-targeted approaches [9]; 20% (n = 2/10) of our RYR2 rare variants lay outside the 64 sequenced exons described by Tester et al. [9]; 40% (n = 4/10) would have been missed by a 3-tiered exon mutation analysis strategy for CPVT diagnosis [20].