Although most of the analyzed lophotrochozoans encode several ADAR paralogs, we demonstrated that only one ADAR gene is upregulated during viral infection in the bivalve C. gigas and in the gastropod H. diversicolor supertexta, and this gene refers to an ADAR1 paralog (Figs. 3 and 4 and Additional file 3: Figure S2). Here, ADAR is linked to viral infectious disease.