MALAT1 and type 2 diabetes mellitus: Particularly, in DR, Yan et al. were the first to document significant aberrations in the expression of MALAT1 in the retinas of STZ-induced diabetic mice (a type I diabetes model), RF/6A (choroid-retinal endothelial) cells cultured in high glucose, and aqueous humors and fibrovascular membranes of type II diabetic patients [98].