However, the presence of ALL-derived CM induced a reduction in the proportion of total CD1a+ CD14−/lo cells, mainly affecting the terminally differentiated CD1ahi CD14−/lo DCs (~30% and 60%, respectively), and concomitantly a notable increase in the proportion of CD1a− CD14+ cells (Figure 1A,B). The gene discussed is CD1A; the disease is acute lymphoblastic leukemia.