Sea cucumber containing polysaccharides consisted of a chondroitin sulfate E backbone, which decreased the level of glucose in the blood by stimulating PI3K/GLUT4 and elevated the phosphorylation of insulin receptors, IRS1, and p85-PI3K in the skeletal muscles of T2DM [90,150,151]. This evidence concerns the gene SLC2A4 and type 2 diabetes mellitus.