The ACS-HN11 tumour model had the highest pimonidazole-positive hypoxic fraction as well as the highest MKI67, POR and SLFN11 expression, but was also p16-positive, thus an ~85–90% likelihood of being HPV-positive, and originated from a tumour that was recurrent post chemoradiotherapy. Here, MKI67 is linked to neoplasm.