POR and head and neck squamous cell carcinoma: These include: POR (NADPH:cytochrome P450 oxidoreductase), which has been reported to catalyse the one-electron reduction of evofosfamide selectively under hypoxia to form Br-IPM [51,52,53]; proliferation markers, since a proliferation metagene can predict evofosfamide sensitivity in HNSCC cell lines in vitro [49] and DNA damage response and mitochondrial electron transport genes (e.g., SLFN11, YME1L1), identified as evofosfamide sensitivity genes through functional genomic screens [54].