Several studies have documented that high-grade gliomas show an increased expression of FGFR1, and decreased expression of FGFR2 [13,39,43,72,83], but in almost all cases, FGFR expression was detected at a global level, and limited or no effort was made to further identify FGFR splice isoforms. Here, FGFR1 is linked to central nervous system cancer.