Sera from rVSVΔG/ANDVGPC-immunized hamsters specifically neutralized ANDV GPC-mediated infection of HUVECs (Figure 3A) and also blocked binding of ANDV GPC to protocadherin-1 (PCDH1) (Figure 3B), the recently identified New World hantavirus receptor [22] suggesting that neutralizing antibodies block infection, at least partly, by preventing virus–receptor recognition. This evidence concerns the gene GYPC and infection.