Interestingly, a recent study showed that in OPSCC specimens, tumor infiltration by Treg cells expressing Tbet+ (Foxp3+ Tbet+ Tregs) was strongly correlated with a concomitant tumor-specific and type 1-oriented intratumoral T cell infiltrate where an increased infiltration Tbet+ Tregs was associated with improved clinical outcomes [83]. Here, TBX21 is linked to neoplasm.