Higher numbers of B cells and CD8+ T cells infiltrating tumors were associated with better clinical outcomes in HPV-positive head and neck squamous cell carcinoma (HNSCC) patients [65] and these observations were further confirmed in a large meta-analysis showing improved overall survival in HPV-driven OPSCCs with increased levels of tumor-infiltrating lymphocytes [66]. The gene discussed is CD8A; the disease is head and neck squamous cell carcinoma.