The immunosuppressive cytokine TGFβ1 impairs NK cells cytotoxicity by promoting the downregulation of NK cells activating receptors including NKp30 and NKG2D [95] and high serum levels of TGFβ1 have been identified in cancer patients, including in HPV-related malignancies [62,96]. Here, TGFB1 is linked to cancer.