The fact that NKG2D receptor is significantly downregulated in patients with HPV-related cancer, coupled with experimental evidence linking the oncoproteins E6 and E7 of HPV in the induction of TGFβ1 in host cells [61] suggest that HPV-induced cancers exploit TGFβ1 signal to escape immune responses mediated by NKG2D receptor. This evidence concerns the gene TGFB1 and cancer.