MT-ND5 and Glucose intolerance: In the present study, we demonstrated that the B6-mtALR mice, carrying the mt-Nd2 (m.4738C>A) variant, showed a slightly but significantly shorter lifespan and a higher susceptibility to diet-induced glucose intolerance than did the B6-mtBPL mice, which carry the wild type C allele at m.4378 in mt-Nd2 and the mutant C allele at m.11902 in mt-Nd5.