In NPC tumor tissues, HOTAIR overexpression promotes angiogenesis and tumor growth by directly activating the transcription of vascular endothelial growth factor-A (VEGF-A) and glucose-regulated protein 78 (GRP78) as well as through GRP78-mediated upregulation of VEGFA and Ang2 expression [36]. This evidence concerns the gene HSPA5 and neoplasm.