Integrins activate four main signaling pathways relevant to cancer initiation, progression, metastasis, angiogenesis, and inflammation: the Rat Sarcoma (RAS)-mitogen activated protein kinases (MAPKs), the phosphoinositid-3-kinase (PI3K)-AKT, the Rho-family GTPases, and the Nuclear Factor kappa B (NF-κB) pathways (for more insights and details, we refer to recently published reviews [37,38,39,40,41,42]. This evidence concerns the gene NFKB1 and cancer.