Immune and inflammatory cells in the tumor microenvironment (i.e., granulocytes, MDSC, monocytes, Dendritic Cells (DC) cells, T cell, B cells, Natural Killer (NK) cells) use overlapping integrins to home, extravasate, and migrate to the tumor microenvironment, namely αLβ2, αMβ2, αXβ2, α4β1, α1β1, α2β1, αVβ3, and α5β1. The gene discussed is AFM; the disease is neoplasm.