The elongation factor-2 kinase (eEF-2K) regulates the invasive phenotype of pancreatic cancer cells by activating a signaling axis consisting of tissue transglutaminase (TG2) and the β1 integrin/uPAR/MMP-2 complex as well as a decrease in SRC activity [53]. The gene discussed is TGM2; the disease is pancreatic neoplasm.