Studies on induced pluripotent stem cell-derived cardiomyocytes have shown that the ARVC-associated missense variant SCN5A-R1898H leads to a significant reduction in peak INa current, and of the abundance of NaV1.5 and N-cadherin clusters at the intercalated disc [13]. The gene discussed is SCN5A; the disease is arrhythmogenic right ventricular cardiomyopathy.