Moreover, missense PKP2 variants identified in SCN5A-negative Brugada syndrome patients were shown to cause a loss of expression of desmosomal protein plakophilin-2, which was associated with decreased INa, reduced number of NaV1.5 channels at the intercalated disc, and increased separation of microtubules from the cell end [33]. The gene discussed is PKP2; the disease is Brugada syndrome.