Among the eleven patients with early onset breast cancer, we identified three women (SA22-18, MV55-17 and LA89-17 in Table 1) carrying known PVs (the c.3607C>T and the c.1016delA mutations in BRCA1 and the c.1670T>G in BRCA2) and two (AM11-17 and TC22-17 in Table 1) with VUS (the c.10040T>C in BRCA2 and the c.3344_3346delAAG in BRCA1). The gene discussed is BRCA1; the disease is breast cancer.