The collected data suggest to very carefully consider two of these variants: the c.5308G>T (p.Gly1770Trp) in BRCA1 gene and the c.7225C>T (p.Pro2409Ser) in BRCA2. The BRCA1 c.5308G>T (p.Gly1770Trp) was detected in a young woman with breast cancer and in two affected relatives (Figure 6a,b). Here, BRCA1 is linked to breast carcinoma.