As CD4+ T cells play a critical role in the pathogenesis of several autoimmune disorders such as multiple sclerosis (MS), rheumatoid arthritis (RA) and SLE, further understanding the mechanistic role of lncRNAs in CD4+ mediated pathology may unveil an untapped treasure trove of drug targets, biomarkers and enhance our knowledge of the immune system. This evidence concerns the gene CD4 and systemic lupus erythematosus.