Considering that most of the αA-CTXs identified by RT-PCR from C. princeps are predicted to target α7 nAChRs (but also α3β2 and other neuronal subtypes) [14], and the potential implications of α7 nAChRs antagonists to treat cancer, and cardiac and renal disorders [22], in this study we aimed to detect, purify, and characterize, toxins with activity at human α7 nAChRs from the venom of this species. This evidence concerns the gene TEAD1 and kidney disorder.