ASAH1 and melanoma: Over the years, in addition to NOE, other ceramide-like compounds have been developed to inhibit AC activity, for example, (1S, 2R) -D-erythro-2 (N-myristoylamino) -1- phenyl 1 - propanol (De-MAPP) and its B13 analog, which potently inhibit AC in vitro in human melanoma cell lines.