In this sense, inhibition of glycolysis by 2-deoxyglucose, activation of AMPK, or inhibition of mTOR inhibited the Warburg effect and protected from renal function loss and cyst progression in diverse preclinical ADPKD with different speeds of progression [109,111,117,118] (Appendix A, Figure A1). The gene discussed is MTOR; the disease is autosomal dominant polycystic kidney disease.