Thus, we evaluated the intracellular signaling pathways involved in UPR (e.g., Inositol Requiring 1 (IRE1), PKR-like ER Kinase (PERK), and Activating Transcription Factor 6 (ATF6)) after leptin treatment in breast cancer cells without find any activation. The gene discussed is EIF2AK3; the disease is breast carcinoma.