IL10 and Sepsis: It has been reported that BM-MSCs activated by lipopolysaccharide (LPS) or tumor necrosis factor-a (TNF-a) reprogram macrophages to increase the production of interleukin-10 (IL-10) by secreting prostaglandin E2 (PGE2) and attenuate sepsis and improve survival in mouse sepsis models [51].