The matched normal-colorectal adenoma result showed the genes with somatic mutations in APC, AMA3, OR6X1, NMBR, EFR3A, RBFOX1, CDH20, BIRC6, KRT84, SLC15A3, FTHL17, and GLCCI1. The matched normal-CRC revealed the genes with somatic mutation in APC, FBXW7, FLT4, GSK3A, ZFP64, NRXN3, TGM7, GRIK1, KIF25, DTL, GNAL, ATF2, OR51E2, CUX1, PPAP2C, CORO1A, OR13J1, KRTAP19-7, POU4F3, PPP1R3C, NARS2, NFATC2, FAM109A, FAM54A, TFR2, ZNF781, RRP8, ZFP36L2, KRT31, RYR1, KIAA1409, NRG1, PGM1, ALPK1, FAM181A, FCRL3, and SDK1 [19]. The gene discussed is RYR1; the disease is colorectal adenoma.