Based on our finding, the normal-CRC showed the candidate genes, including APC, TP53, SOX9, TOPORS, LSR, CALM2, SHISA4, RSPO2, FBXW7, and SYF2. The APC, SOX9, SHISA4, and RSPO2 genes are members of the Wnt signaling pathway [11,65,74,77,78] (Figure 5). This evidence concerns the gene CALM2 and colorectal carcinoma.