Based on our finding, the normal-CRC showed the candidate genes, including APC, TP53, SOX9, TOPORS, LSR, CALM2, SHISA4, RSPO2, FBXW7, and SYF2. The APC, SOX9, SHISA4, and RSPO2 genes are members of the Wnt signaling pathway [11,65,74,77,78] (Figure 5). The gene discussed is SYF2; the disease is colorectal carcinoma.