LGALS3 and Crohn disease: Frolova and colleagues noticed elevated concentrations of Gal-3 in serum samples of UC patients with active disease [8], while Papa Gobbi and associates revealed dysregulated expression of galectins (Gal-1,-3,-4 and -9) in inflamed colon tissues of IBD patients compared with non-inflamed colon tissue samples of patients suffering from non-inflammatory colon diseases, suggesting that galectin-specific signature in the gut may be used for the diagnosis of Crohn’s disease and UC [13].