LGALS3 and colitis: We demonstrated that, during the induction phase of colitis, Gal-3 promotes interleukin (IL)-1β-induced polarization of colonic macrophages towards inflammatory M1 phenotype, while in the recovery phase of colitis Gal-3 controls T cell-driven colon inflammation by down-regulating immunosuppressive function of dendritic cells (DCs) in the gut.