Lim et al. reported that COPD was independently associated with a lower prevalence of EGFR mutation (odd ratio 0.197; 95% CI 0.065–0.600; p < 0.004), and the EGFR mutation rate conversely decreased with increased severity of COPD (p = 0.001) [22]. The gene discussed is EGFR; the disease is chronic obstructive pulmonary disease.