Since vascular endothelial dysfunction and consequent CNS damages have been relevant to ROS [132,133,134] and OS-driven inflammation [135], NRF2 activation is likely to preserve the BBB by maintaining ROS homeostasis that ultimately leads to a decrease in the risk of cerebrovascular, neurodegenerative, and CNS disorders [85,131,136,137,138]. This evidence concerns the gene NFE2L2 and central nervous system disorder.