NFE2L2 and amyotrophic lateral sclerosis: In fact, cerebrovascular and neurodegenerative disorders such as subarachnoid brain hemorrhage, MS, ALS, AD, PD, stroke, and type-2 diabetes mellitus (TD2M) have been tied to dysfunctions of NRF2 activity [6,11,51,121,126,127,128,129,130].