Recent studies demonstrated that the protective effect of interactions between p62 and the NRF2–EpRE signaling pathway inhibited OS damage during cerebral ischemia/ reperfusion in rat undergoing transient middle artery occlusion (tMCAO) and also promoted NRF2 activity to lower the infarct volume and post-ischemic neurocognitive impairments [85,86]. This evidence concerns the gene NFE2L2 and brain ischemia.