CASP3 and ovarian carcinoma: In addition, DAPK1 gene silencing using siRNA prevented the cleavage of caspase-9, caspase-3, and PARP (Figure 4B) as well as the depolarization of mitochondria membranes induced by treating paclitaxel-resistant ovarian cancer cells with gliotoxin followed by paclitaxel (Figure 4C).