Since the discovery of the defective CF gene in 1989, 2065 mutations have been listed in the Cystic Fibrosis Mutation Database (CFTR1) [4], grouped into six distinct classes according to CFTR synthesis, structure and impact at a cellular level, namely: no protein production, defective protein processing, defective channel regulation, decreased conductance, reduced functional CFTR protein and diminished stability [5,6]. This evidence concerns the gene CFTR and cystic fibrosis.