The t(9;22), reciprocal translocation giving rise to the Philadelphia chromosome allows expression of a recombinant chimeric TK protein, BCR-ABL1, which constitutively activates many signaling pathways that are usually tightly regulated, leading to chronic myeloid leukemia (CML) [44]. This evidence concerns the gene TKT and chronic myelogenous leukemia, BCR-ABL1 positive.