Reporter gene functional analyses of progressively truncated 5′-flanking region fragments of the TMBIM6 gene carried out in carcinoma cell lines with different tissue origins (HT1080, MCF-7, DU145, and HepG2) demonstrated similar activity, suggesting that the basal transcription of the TMBIM6 gene is regulated similarly regardless of the cell type (Figure 1B). This evidence concerns the gene TMBIM6 and carcinoma.