First, constitutive release is not observed for most mediators when testing normal mononuclear cells at a much higher cell concentration incubated in medium alone, i.e., undetectable or only low CXCL8 levels are seen compared with the high levels observed for the AML cells in our present study [35] (Figure S2). The gene discussed is CXCL8; the disease is acute myeloid leukemia.