NPM1 and acute myeloid leukemia: Because we observed that mutations in NPM1 and partially cytogenetics correlated with TLR response, we additionally performed Cox regression for uni- and multivariate analysis, including the terms TLR response, patient age (younger or older than 60 years), disease etiology (relapse/secondary vs. de novo AML), NPM1 insertions, Flt3-ITD, and normal/favorable vs. intermediate/adverse karyotype.