The success of these inhibitors in a number of tumour types has led to a search for novel checkpoints—T cell immunoreceptor with Ig and ITIM domains (TIGIT) [56], T cell immunoglobulin and mucin domain-3 (TIM-3) [57] and lymphocyte-activation gene 3 (LAG-3) [58], which appear to be promising therapeutic targets. The gene discussed is LAG3; the disease is neoplasm.