ESR1 and neoplasm: In addition, univariate analysis indicated a worse 5-years % DFS for tumor size >2 cm respect to ≤2 cm (68% vs. 88%; p = 0.002), positive compared to negative nodal status (72% vs. 87%; p = 0.001), high (G3) compared to low (G1–2) histological grade (63% vs. 94%; p < 0.0001), negative compared to positive ER (58% vs. 92%; p < 0.0001) and PR (68% vs. 90%; p < 0.0001) expression, high compared to low Ki67 (68% vs. 90; p < 0.0001).