Antibodies targeting other co-inhibitory molecules, like anti-LAG3 (IMP321 and BMS-986016), anti-TIM3 (LY3321367) or anti-TIGIT (BMS-986207), are being currently tested, notably in breast cancer, and frequently with anti-PD(L)1 (e.g., NCT02913313 and NCT03600090) [116]. Here, CD274 is linked to breast cancer.