Table 1 Shows the top 15 genes. VAMP2 has a HR of 2.9, and downregulation of genes is involved in acute acinar pancreatitis [30]. The CERK gene, with a HR of 2.48, is involved in metastasizing of pancreatic cancer cells and thus leads to cancer development at distant places [31]. This evidence concerns the gene CERK and familial pancreatic carcinoma.