Interestingly, a trial of BNP infusion (2 pmol/kg/min for 60 min) in patients with heart failure and reduced ejection fraction (HFrEF) due to previous myocardial infarction or dilated cardiomyopathy showed that the impaired natriuretic response due to the reduced responsiveness in the distal nephron in patients with HFrEF was comparable to that found in healthy control subjects [5] and the results reported in another previous study [41]. The gene discussed is NPPB; the disease is myocardial infarction.