Deregulation of the DLK1-MEG3 imprinting cluster on chromosome 14q32 is thought to be responsible for the distinct phenotypes observed in the patients of maternal and paternal UPD14 syndromes, which is associated with pre- and postnatal growth restriction, premature puberty, and obesity [30]. This evidence concerns the gene MEG3 and obesity due to melanocortin 4 receptor deficiency.