No distinctive differences were obtained between subgroups of patients with PAD divided on the basis of BMI into subgroups with normal body weight, overweight, or obesity, but it was observed that the concentrations of t-PA Ag and PAI-1 Ag tended to increase in these subgroups while the D-dimer concentrations decreased. The gene discussed is PLAT; the disease is obesity due to melanocortin 4 receptor deficiency.