Positive correlations observed between BMI and t-PA Ag levels and concentrations of PAI-1 Ag and BMI can be associated with high plasma levels of PAI-1 Ag, and manifest an intensive formation of t-PA-PAI-1 complexes, which needs to be supported in further studies on a larger number of overweight or obese patients with PAD. The gene discussed is PLAT; the disease is peripheral arterial disease.