UQCRC2 and cancer: In these cancer cells, tigecycline suppresses COX I and COX II, which are translated in mitochondria, as well as NADH: ubiquinone oxidoreductase subunit B8 (NDUFB8) protein levels, while COX IV (this protein is cytosolically translated), ubiquinol-cytochrome-c reductase core protein 2 (UQCRC2, COX III), succinate dehydrogenase complex flavoprotein subunit A (SDHA) and glucose-regulated protein, 78kDa (GRP78, HSPA5) remain unchanged [29,40].