BMPR2 and idiopathic pulmonary arterial hypertension: Indeed, while it seems accepted that pulmonary microvascular endothelial cells and bone morphogenetic protein receptor 2 (BMPR2)-deficient ECs derived from patients with IPAH are more vulnerable to DNA damage [39,40], it has been demonstrated that this susceptibility is not observed with identical genotoxic stresses in PASMCs [40].