Although our results support a metabolic shift to aerobic glycolysis with an overexpression of glucose transporter Glut1 [21] (Figure S2), we would emphasize that the Warburg effect is not exclusive to a cancer cell phenotype as it has also been observed in other “stressed tissue micro-environments” represented by chronic diseases that include tuberculosis, idiopathic pulmonary fibrosis [22], atherosclerosis [23], and Alzheimer’s disease [24]. Here, SLC2A1 is linked to early-onset autosomal dominant Alzheimer disease.