According to the Hans’ algorithm, DLBCL are subdivided in GCB tumors that are CD10+ or CD10-/BCL6+/MUM1-/IRF4-, and in non-GCB tumors that are CD10-/MUM1+/IRF4+ (BCL6 can be positive or negative) [6]. This evidence concerns the gene MME and diffuse large B-cell lymphoma.