According to the Hans’ algorithm, DLBCL are subdivided in GCB tumors that are CD10+ or CD10-/BCL6+/MUM1-/IRF4-, and in non-GCB tumors that are CD10-/MUM1+/IRF4+ (BCL6 can be positive or negative) [6]. Here, IRF4 is linked to diffuse large B-cell lymphoma.