Despite this, we also report some extreme results, such as that for the protein targets of angiotensin-converting enzyme inhibitors, which were associated with an increased Alzheimer’s disease risk (OR per 10 mmHg lower systolic blood pressure: 13.29; 95% CI: 2.14 to 81.24; p = 0.005; rs4968783). The gene discussed is ACE; the disease is early-onset autosomal dominant Alzheimer disease.