INS and Hyperglycemia: In insulin-treated, clinically stable diabetic dogs, an elevated dMCV was associated with significant risk for moderate to severe hypertonicity (ST ≥ 320 mmol/kg) and moderate to severe hyperglycemia (glucose ≥ 13.9 mmol/kg) but was not associated with risk for moderate to severe increases in measured serum total osmolality (OsMT ≥ 320 mmol/kg).