It is reported that CD30 is expressed on a subset of activated lymphocytes.[11] In addition, CD30 is a well-known diagnostic marker of classical Hodgkin lymphoma (CHL), anaplastic large cell lymphoma (ALCL), primary mediastinal large B-cell lymphoma and primary effusion lymphoma[11] and a prognostic marker of diffuse large B cell lymphoma.[7,12]. Here, TNFRSF8 is linked to diffuse large B-cell lymphoma.