Approximately, 5% of SS patients are reported to develop ML.[4] Earlier work indicated that SS patients were 15 to 20 times more vulnerable to malignant lymphoma (ML) than those without SS.[2] Our novel study suggested that CD30+ cells infiltrated lacrimal glands and conjunctiva in SS patients without ML, and therefore reinforced the previous reports. Here, TNFRSF8 is linked to lymphoma.