ITIH4 and coinfection: It was shown that HIV/HCV coinfection results in immune debilitation due to hepatic cell signaling pathways that are triggered when the HIV gp120 interacts with CD4.[30] Moreover, the presence of HCV interferes in signaling pathways involved in type I interferon release,[33] which leads to antiviral effects.[31,32] The presence of HCV also enhances HIV replication.[48] The CD4 T depletion has shown to have a profibrogenic role, leading the fibrosis progression in HCV infection.[49]