Immune debilitation in HIV/HCV coinfection has been described as a consequence of the hepatic cells signaling pathway that occurs when HIV gp120 interacts with CD4 and C-C chemokine receptor type 5 (CCR5) or CXCR4 receptors and coreceptors.[30] One way of the immune debilitation that occurs in HIV/HCV coinfection could be mediated by the inhibition in interferon function. This evidence concerns the gene ITIH4 and coinfection.