Recently, case-control studies have focused on the association of the CTLA-4 single-nucleotide polymorphism (SNP) rs231775 G>A with the risk of HCC.[7–9] However, Hu et al found that CTLA-4 rs231775 G>A did not confer susceptibility to HCC.[8] Thus, because of the limited numbers of case-control study, the relationship between CTLA-4 rs231775 G>A with HCC susceptibility is not well established. The gene discussed is CTLA4; the disease is hepatocellular carcinoma.