CTLA4 and hepatocellular carcinoma: After adjusting for chronic HBV infection status, age, sex, smoking, and drinking, an association between the CTLA-4 rs3087243 G>A polymorphism and increased risk of HCC was found (GA vs GG: adjusted OR, 1.38; 95% CI, 1.04–1.85; P = .028 and AA/GA vs GG: adjusted OR, 1.43; 95% CI, 1.08–1.89; P = .012; Table 4).