As summarized in Table 5, the haplotype analysis indicated that the frequency of CTLA4 Crs16840252Ars231775Ars3087243Trs733618, Crs16840252Grs231775Ars3087243Trs733618, and other haplotypes significantly increased the risk of HCC. The gene discussed is CTLA4; the disease is hepatocellular carcinoma.